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Development of Volatile Organic Compounds(VOCs) Sampling Device for Qualitative Analysis in Exhaled Breath using Thermal Desorption- Gas Chromatography/Mass Spectrometry (TD-GC/MS)

TD-GC/MS를 이용한 호흡 가스 VOC 포집 장치 제작 및 정성분석

목차

1. Introduction 3
1.1 Volatile Organic Compounds (VOCs) in Exhaled Breath 4
1.1.1 Saturated hydrocarbons 8
1.1.2 Acetone 11
1.1.3 Isoprene 14
1.2 VOCs analysis using TD-GC-MS 18
1.3 The Purpose of Study 28
2. Experimental 30
2.1 Human Subjects 30
2.2 Hardware 32
2.3 Software 38
2.4 Exhaled Breath Collection and Sampling 39
2.5 Analytical Methods 41
2.5.1 Sorbent tube Desorption 41
2.5.2 TD-GC/MS Analysis 43
2.5.3 Data Analysis 47
3. Results 48
3.1 Setup of the Analytical Procedure 48
3.2 Quality Analysis 65
3.3 Repeatability 71
3.4 Reproducibility 76
4. Conclusion 88
5. References 90

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