Two Facile General Methods for the Conjugation of Three Different Molecules
- 주제(키워드) 도움말 Conjugation chemistry , Bioconjugation , Tripodal conjugation , Click reaction
- 발행기관 WILEY-V C H VERLAG GMBH
- 발행년도 2021
- 총서유형 Journal
- 본문언어 영어
초록/요약 도움말
In the quest to synthesize compounds that are uniquely optimized for fighting each individual target disease, the importance of developing a new methodology for the bioconjugation of compounds with different functional groups or biological activities cannot be overemphasized. This study investigates two novel methods for click reaction: coupling a molecule with three functional compounds by repetitive copper(I) catalyzed azide/alkyne 1,3-dipolar cycloadditions. Method A uses three copper(I) catalyzed azide/alkyne 1,3-dipolar cycloadditions in series. Method B uses two copper(I) catalyzed azide/alkyne 1,3-dipolar cycloadditions and one conjugation reaction of amine and isothiocyanate.
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