Combination Therapy for Cancer Treatment, Photoacoustic Imaging Combined with Exosome-based Photodynamic and Immunotherapy
- 주제(키워드) exosome , cancer
- 발행기관 서강대학교 일반대학원
- 지도교수 김현철
- 발행년도 2021
- 학위수여년월 2021. 2
- 학위명 석사
- 학과 및 전공 일반대학원 화공생명공학과
- UCI I804:11029-000000065782
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
Exosomes are extracellular vesicles used for cell-to-cell communication. For this reason, many studies are being conducted as a means of drug delivery. In particular, immunotherapy is a new emerging technology in cancer treatment, and by producing or enhancing antibodies and immune systems, it seems to be a means to solve various diseases known to be incurable until now. In this study, tumor-derived reassembled exosomes were loaded with chlorin e6 and used as an immune stimulator as well as a drug delivery system. These reassembled exosomes can target tumor cells like before transformation, and are loaded with chlorin e6, so they can be visualized by photoacoustic imaging. In addition, it has shown the potential as an effective therapeutic agent by generating free radicals under laser irradiation and increasing the release of cytokines from immune cells. In conclusion, reassembled exosomes derived from tumors loaded with chlorin e6 present a novel method for complex immunotherapy treatment.
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