Thermo-responsive release of β-Lapachone from PNIPAM-modified hydrogels
- 주제(키워드) Drug delivery system
- 발행기관 서강대학교 일반대학원
- 지도교수 정봉근
- 발행년도 2018
- 학위수여년월 2018. 8
- 학위명 석사
- 학과 및 전공 일반대학원 융합의생명공학과
- 실제URI http://www.dcollection.net/handler/sogang/000000063489
- UCI I804:11029-000000063489
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
Temperature- and pH-sensitive poly-N-isopropyl acrylamide (PNIPAM) hydrogels have been modified with different acrylic acid (AAc) contents for the efficient control of lower critical solution temperature (LCST). In this study, PNIPAM-co-AAc hydrogels were fabricated by the co-polymerization of NIPAM and the addition of AAc and showed two volume phase transitions in comparison with PNIPAM. The more the AAc content increased in the PNIPAM hydrogel, the higher the transition temperature was. The controlled drug release performance of PNIPAM-co-AAc hydrogels loaded with β-lapachone was attributed to the AAc content ratio and was efficiently triggered in response to temperature and pH. Finally, a colorimetric cell proliferation assay and direct fluorescence-based live/dead staining were used to confirm the concurrence on drug release profiles. These results demonstrated that the double controlled drug releasing PNIPAM-based hydrogel could be a promising nanocarrier for effective drug release in response to temperature and pH.
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