Biohybrids Consisted of Cytochrome c and Gold Nanoparticle to Enhance the Stability of Electrochemical Signal in Biochip
- 발행기관 서강대학교 일반대학원
- 지도교수 최정우
- 발행년도 2017
- 학위수여년월 2017. 2
- 학위명 석사
- 학과 및 전공 일반대학원 융합의생명공학과
- 실제URI http://www.dcollection.net/handler/sogang/000000061405
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
In this study, a hybrid material composed of metalloproteins and nanoparticles was fabricated by the enzyme precipitate coating method to enhance the intensity and stability of the signals in bioelectronic devices. Formation of the material and immobilization on a gold substrate were confirmed by scanning electron microscopy and atomic force microscopy, for which the results were compared against those of metalloprotein-capped nanoparticles not subjected to the method. The electrochemical properties and stability of the hybrid material and those of metalloproteins without nanoparticles were compared and investigated by cyclic voltammetry. The experimental results indicate that the hybrid material enhanced electrochemical signals and had high stability. Thus, the method used in this study could be broadly applied as an alternative to fabricate bioelectronics devices, so as to overcome the problems of low signal intensity and stability in such devices.
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