Development of Multi-Functional Surface-Modified Nanocarrier Systems
- 발행기관 서강대학교 일반대학원
- 지도교수 신관우
- 발행년도 2026
- 학위수여년월 2026. 2
- 학위명 석사
- 학과 및 전공 일반대학원 화학과
- 실제URI http://www.dcollection.net/handler/sogang/000000082857
- UCI I804:11029-000000082857
- 본문언어 영어
- 저작권 논문은 저작권에 의해 보호받습니다.
목차
Acknowledgements i
Contents ii
List of Figures and Table iv
Abstract v
1. Introduction １
2. Experimental Details ５
2.1. Preparation of FN-GUVs with Hep-H ５
2.2. Preparation of FN-SUVs with Hep-H ７
2.3. Dynamic Light Scattering and Zeta Potential Measurements ８
2.4. Quantification of Hep-H Incorporation Efficiency ９
2.5. Quantification of Fibronectin Efficiency ９
2.6. Measurement of H₂O₂ Scavenging Activity １０
2.7. WST-based Cytotoxicity Assay １１
2.8. Ulcerative Colitis Mice Model and Treatment １２
2.9. Disease Activity Index (DAI) and Body Weight Monitoring １３
2.10. Tissue Preparation and Western Blotting １３
3. Results and Discussion １４
3.1. Strategies for Combining FN-SUV and Hep-H １４
3.2. Characterization of Functionalized Nanoliposomes １８
3.3. Hep-H Loading and Fibronectin Coating Efficiency by Method ２２
3.4. Cell Toxicity and Stability Analysis ２６
3.5. HepH-Lip-FN Improved Healing in Mice with UC ２７
4. Conclusion ３１
References ３２
