Flexible Acid-Resistant Films via Disulfide Bond Reconstruction of Human Hair-Derived Keratin
- 주제어 (키워드) Keratin , Disulfidebond
- 발행기관 서강대학교 일반대학원
- 지도교수 신관우
- 발행년도 2025
- 학위수여년월 2025. 2
- 학위명 석사
- 학과 및 전공 일반대학원 화학과
- 실제 URI http://www.dcollection.net/handler/sogang/000000079872
- UCI I804:11029-000000079872
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권 보호를 받습니다.
초록 (요약문)
Keratin is one of the most abundant materials readily available from natural resorces, including wool, hair, and hooves, which are byproducts of various organisms. In addition, keratin is both biodegradable and biocompatible, and boasts excellent acid resistance and broad physical/chemical stability, particularly when compared to other biopolymeric materials. These distintive properties of naturally derived keratin can be leveraged to create films for direct application in high acid-resistance coating. Film prepared via solvent casting, which holds the advantage of a very simple process. However, conventional keratin-only films are too vulnerable to water, necessiating additional cross-linking to overcome this issue. Yet, even after cross-linking, films are too brittle to be universally utilized. In this study, we aimed to mitigate this challenge by enhancing the alpha- helical conformation associated with the flexibility of regenerated keratin using polyols. Furthermore, in the process of extracting keratin from human hair, we induced internal disulfide bond reconstruction within the keratin molecules using 1,4-dithiothreitol. This eliminated the need for post-cross-linking processes, whcih are the main cause of brittleness in the keratin films. Thus, this study aims to leverage the inherent advantages of Keratin itself to efficiently pursue their application in high-acid-resistance and flexible coating material. Keywords: Acid-resistance, keratin, polyol, 1,4-dithiothreitol, disulfide bond reconstruction , flexible
more목차
1. Introduction 1
2. Experimental details 4
2.1. Preparation of materials 4
2.2. Analytical technique. 4
2.3. Experimental methods 5
Optimization 5
Optimized procedure 7
Comparison of appearance 7
Acid resistance test 8
Verification of actual protection performance 9
3. Results and discussion 10
3.1. Optimization of procedure 10
3.2. Comparison of appearance 12
3.3. Acid resistance test 13
3.4. Verification of actual protection performance 16
Conclusion 18
References 19
