서강대학교

목차

Part I. Synthetic strategies toward ortho-3-propanoate substituted aryl phosphonates by three-component coupling reactions of arynes, hosphites, and acrylates 1
1. Introduction 1
2. Results and Discussion 2
2.1 Reaction Optimization 2
2.2 Substrate Scope of actylates 4
2.3 Substrate Scope of alpha- and beta-Substituted Acetylates 6
2.4 Arbuzov-type reactions of α-substituted acrylates 8
2.5 Substrate Scope of Phosphites 10
2.6 Substrate Scope of benzynes intermediates 11
2.7 Applications 13
2.8 Proposed Mechanism 14
3. Conclusion 15
4. Experimental Section 15
4.1 General Information 15
4.2 General Procedure 16
5. Appendix
5.1 NMR Spectra (1H NMR, 13C NMR, 19F NMR and 31P NMR)
6. References 64
Part II. Annulation of phosphites with arynes using gold-copper dual catalysis 66
1. Introduction 66
2. Results and Discussion 67
2.1 Reaction Optimization 67
2.3 Substrate Scope of benzynes intermediates 72
2.4 Substrate Scope of phosphites 74
2.5 Applications 75
2.6 Proposed Mechanism 77
3. Conclusion 78
4. Experimental Section 78
4.1 General Information 78
4.2 General procedures for the preparation of aryne precursors 79
4.3 Typical Procedure for benzoxaphosphole 5-oxide 83
5. Appendix 106
5.1 NMR Spectra (1H NMR, 13C NMR, 19F NMR and 31P NMR) 106
6. References 108