Assessing Skin Permeation of Benzalkonium Chloride on Porcine Skin : A Comparative Study Using Franz Diffusion Cell and LC-MS
- 주제어 (키워드) Benzalkonium chloride , skin absorption , Franz diffusion cell , LC-MS , porcine skin , cumulative amount permeated , Flux , permeability coefficient; 염화 벤잘코늄 , 피부흡수시험 , 돼지피부 , 피부 누적 투과량 , 투과계수
- 발행기관 서강대학교 일반대학원
- 지도교수 오한빈
- 발행년도 2024
- 학위수여년월 2024. 2
- 학위명 석사
- 학과 및 전공 일반대학원 화학과
- 실제URI http://www.dcollection.net/handler/sogang/000000076652
- UCI I804:11029-000000076652
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권 보호를 받습니다.
목차
1. Introduction 1
2. Materials 5
2.1. Materials and chemicals 5
2.2. Skin preparation 6
2.3. Fabrics 6
2.4. Dosing solutions 7
2.5. Receptor fluid 7
3. Method 9
3.1. Permeation test 9
3.2. Sample preparation 11
3.3. Liquid chromatography 13
3.4. Mass spectrometry 14
3.5. Data analysis (Flux, Kp) 16
4. Results 17
4.1. Liquid contact penetration experiment 17
4.1.1. Experiment using artificial sweat with a pH 4.7 17
4.1.2. Experiment using artificial sweat with a pH 6.5 22
4.2. Penetration experiments with fabric contact 28
4.2.1. Experiment using artificial sweat with a pH 4.7 28
4.2.2. Experiment using artificial sweat with a pH 6.5 32
5. Discussion 38
5.1. Flux value 38
5.2. Permeation coefficient (Kp) 40
5.3. Analysis of residual amount of BAC chains in the skin 43
6. Conclusion 44
7. References 45
