Negative Mold Printing Technique for Fabrication of Controllable Hydrogel-Based 3D Hollow Structures and Complex Artificial Organ Scaffolds
- 주제어 (키워드) 3D printing , hollow structure , diffusion , artificial organ , bioengineering
- 발행기관 서강대학교 일반대학원
- 지도교수 신관우
- 발행년도 2023
- 학위수여년월 2023. 8
- 학위명 석사
- 학과 및 전공 일반대학원 화학과
- 실제 URI http://www.dcollection.net/handler/sogang/000000076302
- UCI I804:11029-000000076302
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권 보호를 받습니다.
초록 (요약문)
The development of artificial organs, particularly hollow organs like blood vessels, the heart, stomach, and intestines, has become a major focus in tissue engineering. One of the current challenges is creating constructs that closely resemble native tissue and organs. To address this challenge, We develop a novel strategy using negative mold printing system to create hollow structures that mimic hollow organs in the body. The technique involves using a fugitive ink made of CaCl2, and Pluronic F127 (PF127-Ca2+), which is extruded onto a mixture of alginate and gelatin. The calcium ions in the PF127- Ca2+ diffuse and crosslink the alginate to produce a hollow hydrogel construct that closely resembles the hollow organs. The concentration of CaCl2, embedding time, and nozzle diameter are controlled to achieve the desired shape properties of hollow structure. This 3D negative mold printing system has the potential to be used in the study of artificial organs, to replace or understand the organism's digestive system.
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