Synthesis of Pyrimidinyl Benzazolyl Urea Derivatives as Antimicrobial and Antioxidant Agents
- 주제(키워드) 도움말 Pyrimidinyl benzazolyl urea , potassium tert-butoxide , antibacterial activity , antifungal activity , antioxidant activity
- 발행기관 TAYLOR & FRANCIS LTD
- 발행년도 2021
- 총서유형 Journal
- 본문언어 영어
초록/요약 도움말
A library of pyrimidinyl benzazolyl urea derivatives were synthesized from pyrimidine-2- amine and methyl benzazolylcarbamate in the presence of potassium tert-butoxide in DMF. The compounds with benzothiazolyl and benzimidazolyl moieties having chloro and nitro substituents on the aromatic ring exhibited prominent antibacterial activity against Bacillus subtilus. Nitro substituted pyrimidinyl benzothiazolyl urea and pyrimidinyl benzimidazolyl urea displayed prominent antifungal activity against Asperigellus niger. The compounds with benzoxazole moiety showed greater radical scavenging activity than those with benzothiazole and benzimidazole units.
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