Lysosome-instructed Self-assembly of Amino Acid-functionalized Perylenediimide for the Multidrug-resistant Cancer Treatment
- 주제(키워드) multi drug resistance , lysosomal-mediated apoptosis , supramolecular self-assembly
- 발행기관 서강대학교 일반대학원
- 지도교수 김현철
- 발행년도 2021
- 학위수여년월 2021. 2
- 학위명 석사
- 학과 및 전공 일반대학원 화공생명공학과
- UCI I804:11029-000000065781
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
Multidrug resistance (MDR) of cancer cells reduces chemotherapeutic efficacy by preventing drug accumulation through drug efflux pump and lysosomal sequestration/exocytosis. Herein, lysosome-targeting organelle-localization-induced supramolecular self-assembly (OLISA) of perylene diimide (PDI) derivatives is presented as a powerful strategy to overcome anticancer resistance. Stimulated by the lysosomal low pH, the amphiphilic PDI derivatives functionalized with amino acids (PDI-AAs) construct fibrous self-assembly inside the lysosomes, causing cancer cell apoptosis by lysosomal rupture with negligible apoptosis for normal cell. The agglomerated assemblies were not removed by lysosomal exocytosis, thereby displaying a 10.7-fold higher anticancer efficacy on MDR cancer compared to a doxorubicin chemotherapeutic agent. The MDR-circumventing capability support PDI-AAs as potential candidates for the treatment of MDR cancer cells by lysosome-targeting OLISA.
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