Biohybrid robot composed of muscle bundle/hyaluronic acid modified gold nanoparticles to monitor inotrope effect
- 주제(키워드) Biohybrid robot , HA-AuNPs , muscle bundle , Inotrope effect , Drug screening
- 발행기관 서강대학교 일반대학원
- 지도교수 최정우
- 발행년도 2020
- 학위수여년월 2020. 8
- 학위명 석사
- 학과 및 전공 일반대학원 화공생명공학과
- UCI I804:11029-000000065474
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
Biohybrid robotics has the potential to dynamically sense, respond and adapt to changing environmental loads, therefore it can be applied for drug screening instead of human clinical trials. However, since the muscle cell-based bioactuator has a limitation that the driving force is weak, it is difficult to evaluate effect of the drugs by distinguishing changes in the motion of the biohybrid robot. To overcome this limitation, in this study, hyaluronic acid modified gold nanoparticle (HA-AuNPs) was introduced into muscle bundle based biohybrid robot which move forward in response to electrical stimulation. The motion of fabricated biohybrid robot was enhanced because the differentiation of muscle bundles and the electrical conductivity of the hydrogel composed of muscle bundles were improved by HA-AuNPs. In addition, biohybrid robot showed changes in the motion by inotropic drugs. In conclusion, this fabricated biohybrid robot has possibility to applied for neuromuscular disease drug screening by combining nervous tissues such as brain organoids.
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