Biophotosensor composed of bacteriorhodopsin with Ni/TiO2 hybrid nanoparticles
- 주제(키워드) Biophotosensor , Cell signaling , Bacteriorhodopsin , Photocurrent , Ni/TiO2 hybrid nanoparticle
- 발행기관 서강대학교 일반대학원
- 지도교수 최정우
- 발행년도 2020
- 학위수여년월 2020. 2
- 학위명 석사
- 학과 및 전공 일반대학원 화공생명공학과
- UCI I804:11029-000000065149
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
Cell signaling is a process of intercellular communication in which perceived external stimuli are transmitted to other cells. Disruption of this process can cause serious disease such as cancer and autoimmune diseases. For this reason, it is important to control the induction and measurement of cell signaling by applying appropriate stimuli to cells. From this point of view, in this research, the biophotosensor composed of bacteriorhodopsin (bR) and Ni/TiO2 hybrid nanoparticle (Ni/TiO2 NP) was fabricated to induce the cell signaling. bR produced photocurrent to stimulate cell by absorbing light from wavelengths around 560 nm. In addition, Ni/TiO2 NP was introduced to amplify the photocurrent. The result indicates that the change of membrane potential was induceed by biophotosensor. This fabricated bR and Ni/TiO2 NP based biophotosensor can be applied as a novel platform for generation of cell signaling in cells that constitute artificial eyes.
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