서강대학교

초록/요약

The noble metallic nanoparticle have been studied for the development of sensitive biosensing their particular properties such as surface plasmon resonance, broaden surface area, high electroconductivity, etc. These properties could be easily utilized to enhance the signal intensity in diverse analytical methods. In this study, noble metallic nanoparticle-based biosensors were successfully developed with highly sensitive manner. First, eletrochemical dopamine biosensors composed of silver encapsulated MoS2 hybrid nanoparticle was developed. Silver encapsulated MoS2 hybrid nanoparticle enhanced the redox peaks of the dopamine using electrochemical analysis. Second double/core shell Ag/polypyrrole (Ppy)/Ag nanostructure was fabricated for sensitive detection of caspase-3. In this sensor, Au nanoparticle was modified by the Raman-active dye and the specific peptide sequence, which could degrade by the caspase-3 selectively. Finally, metal enhanced fluorescence (MEF)-based gold nanocomplex was developed for the highly-sensitive detection of caspase-3 with rapid and simple manner. Through these signal-enhanced biosensors with the noble metallic nanoparticles, biomarkers such as dopamine and caspase-3 could be successfully measured with highly-sensitive manner.