Bioactuator composed of muscle/MoS2 based biohybrid to investigate drug cytotoxicity
- 주제(키워드) Electrochemical actuator , Cardiac myocytes , MoS2 NNs , Bioactuator , Doxorubicin , Drug cytotoxicity
- 발행기관 서강대학교 일반대학원
- 지도교수 최정우
- 발행년도 2019
- 학위수여년월 2019. 2
- 학위명 석사
- 학과 및 전공 일반대학원 화공생명공학과
- 실제URI http://www.dcollection.net/handler/sogang/000000064154
- UCI I804:11029-000000064154
- 본문언어 영어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
Doxorubicin has been widely used as anticancer agent for effective cancer treatment. However, it is one of the drugs that causes heart failure through cytotoxicity and cardiac toxicity by fatal problem such as destruction of calcium homeostasis and increased oxidative stress. According to these problem, investigation of drug cytotoxicity is important issue for effective cancer treatment. From this point of view, in this study, the bioactuator composed of cell (cardiac muscle cell), kapton, gold (Au) and molybdenum disulfide (MoS2) is fabricated to investigate the cytotoxicity of doxorubicin on the cardiac muscle cell based platform. The result indicates that the movement of the fabricated bioactuator decreased with the treatment of doxorubicin. This fabricated cell/kapton/Au/MoS2 bioactuator can be applied to develop the efficient disease model platform for drug cytotoxicity investigation.
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