Metal nanoparticle conjugated graphene oxide for targeted photothermal therapy
- 주제(키워드) Graphene oxide , Photothermal therapy , tumor targeting
- 발행기관 서강대학교 일반대학원
- 지도교수 정봉근
- 발행년도 2017
- 학위수여년월 2017. 2
- 학위명 석사
- 학과 및 전공 일반대학원 기계공학과
- 실제URI http://www.dcollection.net/handler/sogang/000000061448
- 본문언어 한국어
- 저작권 서강대학교 논문은 저작권보호를 받습니다.
초록/요약
Cancer is one of the main causes of morbidity and mortality in the world. Although a number of techniques are available for treatment, the methods have a number of drawbacks, destroying healthy tissues and cells, to cause various side effects. Here we present the synthesis and in vitro application of a composite nanomaterial, folic acid (FA)-coated graphene oxide (GO) nanosheets functionalized with manganese dioxide (MnO2) nanoparticles. While the FA-coated GO nanosheets can be used for targeted photothermal therapy when irradiated with a near infrared (NIR) light, MnO2 nanoparticles degrade hydrogen peroxide (H2O2) in the tumor microenvironment, countering hypoxia. Therefore MnO2-FA-GO could be potentially powerful therapeutic nanosheets for targeting photothermal therapy.
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