서강대학교

초록/요약

Recently, three-dimensional (3D) printing is being applied to produce biomedical scaffolds, having 3D complex architectures. In order to deposit biomaterials in three-dimension, the bioink materials, which are usually soft and viscous, must be additively layered with a greater stability. Therefore, 3D bioinks must satisfy the following criteria; rapid crosslinking capability, biocompatibility for cells or tissues, a short-term structural stability with a long-term degradable property. Most importantly, the materials must support cell adhesion, differentiation and proliferation. Gelatin modified by methacryloyl side groups has gained the increased attention as a 3D bioink, because it has the inherent bioactivity and tailorability of photo-crosslinking. In order to increase the mechanical properties with improved short-term stability, we further investigated this materials, by adding alginate and sugar. We developed 3D printable hydrogel ink and simple fabrication process for bone scaffold which improved porosity and homogeneous cell distribution.