A Synthesis of Enantiomerically Pure Benzoxazine and Tetrahydroquinoline Derivatives from a Chiral Aziridine : A Formal Synthesis of (-)-Swainsonine from a Chiral Aziridine
- 주제(키워드) Benzoxazine and Tetrahydroquinoline , (-)-Swainsonine
- 발행기관 서강대학교 대학원
- 지도교수 이원구
- 발행년도 2010
- 학위수여년월 2010. 2
- 학위명 석사
- 학과 일반대학원 화학과
- 실제URI http://www.dcollection.net/handler/sogang/000000045835
- 본문언어 영어
- 저작권 서강대학교의 논문은 저작권에 의해 보호받습니다
초록/요약
A synthesis of enantiomerically pure 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine and 2-hydroxymethyl-1,2,3,4-tetrahydroquinoline derivatives was successfully achieved via a palladium-catalyzed intramolecular bond formation between the nitrogen originated from aziridine and the halogenated aromatic carbon.
more초록/요약
Eanatiomerically pure (-)-swainsonine was synthesized efficiently from chiral aiziridine-2-carboxylate using mesylation and intramolecular cyclization.
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