Studies on 5-Substituted N-Aryl or 3-Aryl-Indole Derivatives as Potential RTK Inhibitors
- 발행기관 서강대학교 화학과대학원
- 지도교수 문봉진
- 발행년도 2010
- 학위수여년월 2010. 2
- 학위명 석사
- 학과 일반대학원 화학과
- 실제URI http://www.dcollection.net/handler/sogang/000000045743
- 본문언어 한국어
- 저작권 서강대학교의 논문은 저작권에 의해 보호받습니다
초록/요약
Receptor Tyrosine Kinase (RTK) has been known as the promising target for an anticancer drug. Recently, several RTK inhibitors launched as anti-cancer drugs and showed good profiles clinically, but it still needs to find novel RTK inhibitors, especially to overcome the resistance. We identified the 5-substituted indoles as RTK inhibitors, and investigated the influence of various 5-substituents on the activity, including aryl rings, amines, amides, or ureas, and etc. Using 5-nitro indoles, we synthesized 3-aryl or N-aryl derivatives with 5-substiuents, and evaluated their inhibitory activities on VEGF-, or EGF-RTK. Also, the inhibitory effects on human tumor cell growth were examined.
more